Introduction: Diabetes mellitus is a global public health issue that has a prevalence of between 5-8% in different parts of Iran. One of the most serious complications of diabetic foot ulcer and chronic complications of diabetes mellitus is one of the leading causes of Morbidity and amputation in patients with diabetes. On the other hand, amputations in patients with diabetes are three-year survival rate is only 50 percent. Hyperbaric oxygen a treat medical that the patient is in a closed chamber exposed to oxygen at 100 percent pure at a pressure higher than the pressure at sea (4/1 atm or higher) are placed. Patient can breathe pure oxygen that tissue levels and further increases healing. The purpose of this study, an overview of the use of hyperbaric oxygen in the treatment of Diabetic foot.

Methodology: Present study was done to review the literature in search of Persian databases such as ( Iranmedex, SID, Magiran) and English databases such as ( EBSCO, Pub med, ProQuest , Google Scholars) With Hyperbaric Oxygen Therapy and diabetic foot keywords related to the years 1987 to 2012.

Results: Hyperbaric oxygen is beneficial for diabetic ulcers and Increases the oxygen level in tissue and healing mechanisms by angiogenesis, collagen synthesis, increase the response of fibroblasts, blood vessels and increases the antibacterial activity of leukocytes also has some side effects such as toxicity with oxygen in the brain and lungs , barotraumas of the middle ear, Myopia and seizures that for reduce the side effects is recommended that patients monitored by doctors and nurses who do Hyperbaric Oxygen Therapy.

Conclusion: Results showed that hyperbaric oxygen may reduce the risk of major amputation and accelerates healing rate after one year but further studies should be treated in the clinical trials done to ensure greater accuracy as the standard treatment for hyper oxygen therapy in the treatment of diabetic foot ulcers utilized.