Introduction: Depression is one of the most prevalent mental disorders in patients with diabetes, which affects on cooperation in implementation of treatment measures, consequences of therapeutic and diabetes complications. Is thought, Low self-esteem is endangering balance of mental and emotional person and is caused development of depression. This study was performing with goal of comparison of self-esteem and diabetes complications in depressed and non-depressed patients with type 2 diabetes. 

Methodology: In this analytical study case- control with method of sampling of based on aim, 259 hospitalization diabetic patients (120 depressed patients and 139 non-depressed patients) were selected in teaching hospitals of Qom University of medical science. Data were collected by using demographic, Rosenberg self- esteem and Short form Beck Depression questionnaires and then computer software SPSS 18 was used for data analysis. Descriptive statistics, chi-square, independent t- test, spearman correlation tests were used.

Results: Tests results showed that Age and blood sugar control had not significantly different between cases and controls (P>0/05), but economic status, marital status, duration, complications of diabetes (diabetic foot, amputation, and visual disturbances) and self- esteem between the two groups depressed and non-depressed patients with diabetes had significant difference (P<0/05). The mean self- esteem scores for non-depressed patients with diabetes were 24/07± 3/65 and the depressed group was 18/45 ± 4/51.

Conclusion: Medium and low self-esteem and complication of diabetes among depressed diabetic patients were more non- depressed patients. Acording to results seem, assessment of depression and self- esteem patients is better, using for routine healthy assessment of diabetic patients and carry out privative and grouped implementation for groups of high risk, for decrease depression and promotion self-esteem patients. Recommended qualitative studies carry out for diagnosis infective factors on depression in additional survey affect program of promotion of self-esteem on depression this patients particularly high risk patients with longitudinal design.