Volume 13, Issue 1 (2-2025)                   J Diabetes Nurs 2025, 13(1): 2621-2632 | Back to browse issues page

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Sivandzadeh G R, Aminisefat A, Iraj S, Fateme S, Tahani M. The Role of Insulin Resistance in the Progression of Non-Alcoholic Fatty Liver Disease. J Diabetes Nurs 2025; 13 (1) :2621-2632
URL: http://jdn.zbmu.ac.ir/article-1-670-en.html
The Role of Insulin Resistance in the Progression of Non-Alcoholic Fatty Liver Disease
Gholam Reza Sivandzadeh , Alireza Aminisefat , Shahramian Iraj , Sharafi Fateme , Masoud Tahani
Shiraz University of Medical Sciences
Abstract:   (704 Views)
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disorder worldwide and one of the leading causes of liver-related mortality. It encompasses a spectrum of hepatic abnormalities, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), advanced fibrosis, and cirrhosis. NAFLD is considered the hepatic manifestation of metabolic syndrome, with insulin resistance as a key pathophysiological feature. Obesity, insulin resistance, and type 2 diabetes mellitus (T2DM) are the major risk factors for disease progression in NAFLD. Evidence also indicates that NAFLD further aggravates hepatic and systemic insulin resistance, predisposes individuals to atherogenic dyslipidemia, and promotes the systemic release of pro-inflammatory cytokines and hepatokines, which may contribute to the development of T2DM. This narrative review aims to explore the relationship between T2DM, insulin resistance, and NAFLD, with an emphasis on the underlying pathophysiological mechanisms and additional factors involved in the progression of NAFLD.
 
Keywords: Non-alcoholic fatty liver disease, Type II diabetes mellitus, Insulin resistance.
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Type of Study: Letter to Editor | Subject: Interventions for diabetes
Received: 2025/04/7 | Accepted: 2025/08/10 | Published: 2025/06/9
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