Introduction: The global prevalence of diabetes exceeded the estimated value of 30 million in 1985 and rose to 177 million in 2000. It is estimated that the total number of diabetic patients will increase to 439 million in 2030.

The therapeutic regimen is valuable in managing the type II diabetes patients. It seems that e-learning is essential for all the patients to guarantee the access to the instructions. Nowadays, multimedia instructions by using compact disks are deemed as a modern way of learning to convey the concepts in a broad sense.

Material and Methods: This quasi-experimental study was conducted on 85 patients with type II diabetes referred to Shahid Qodsi health center in Mashhad, Iran. The samples were selected using convenience sampling method and they were placed in two groups, namely, the intervention and control groups who were educated by electronic and routine learning, respectively. The intervention period was considered to be two month. Data obtained by completing the questionnaire pre- and post-intervention and taking blood samples to measure the glycated hemoglobin. Data analysis was performed using SPSS version 17, paired and independent t-tests, and repeated measures ANOVA.

Results: According to the results, the intervention group revealed a significant increment in average value of regimen compliance in comparison to the control group (P<0.05). After the end of intervention period, the mean and standard deviation of glycated hemoglobin were significant in both groups.

Conclusion: Regarding the results, e-learning has a great effect on adherence to the therapeutic regimen and reduction in costs and traffic. This procedure could be used with the least facilities and is affordable. Therefore, it is recommended to train the nurses and encourage them to use this method to educate the diabetic patients.