Introduction: Diabetic patients are at a high risk of nephropathy, which is known to impose physical, emotional, psychological, and economic burden on the patients, their families, and society. Moreover, nephropathy hinders the treatment of diabetic patients leading to several complications. This study aimed to evaluate the risk factors of proteinuria in patients with type II diabetes.

Methodology: This cross-sectional study was conducted in Taleghani Hospital of Kermanshah city, Iran in 2014. Data were collected from diabetic patients with glomerular filtration rate (GFR) of >60 through the evaluation of high-density lipoprotein (HDL), cholesterol, triglycerides (TG), and low-density lipoprotein (LDL). Data analysis was performed in SPSS V.21.

Results: In this study, HDL cholesterol (OR=0.96, P=0.001) and gender (OR=0.36, P=0.001) were observed to be significant predictors of the incidence of proteinuria. However, factors such as age, duration of diabetes, non-HDL cholesterol, TG, LDL, and anemia were not significant predictors of proteinuria in this model (P>0.05).

Conclusion: According to the results of this study, gender and HDL cholesterol level are effective in the incidence of proteinuria  in patients with type II diabetes and GFR of >60. Therefore, early detection and examination of this factor could delay the progression of nephropathy and be used in the implementation of interventional programs to manage the complications of diabetes.