Hamidreza Badeli, Mohammad Hassan Mohammadi, Afagh Hassanzadeh Rad, Abdorreza Medghalchi, Setila Dalili,
Volume 5, Issue 1 (3-2017)
Abstract
Introduction: In developed countries, overweight and obesity are important factors among children and adults. Overweight in childhood is an effective factor in incidence of chronic diseases, such as diabetes and insulin resistance, and overweight in adulthood. The aim of this study was to investigate the risk factors for childhood obesity to prevent type II diabetes.
Materials and Methods: This was a case-control study. The case group included students who had a body mass index percentile of 85% or higher (n=120). The control group comprised of students with body mass index percentile of 85% or lower (n=480). Children’s demographic characteristics, the child and parents’ weight, type of delivery, student’s weight at the time of entering elementary school, and nutritional status of the child were compared.
Results: The results showed that mothers’ and fathers’ weight in obese children were significantly higher compared to others (P=0.00 and P=0.024, respectively). Type of nutrition was significantly associated with obesity (P<0.05).
Conclusion: We recommend the consumption of low-fat dairy products, low-sugar marmalades, whole grain spaghetti, and standard fast foods as an alternative for non-standard and high-fat foods.
Fatemeh Kharaee, Setila Dalili, Abdolreza Medghalchi, Shahin Koohmanaee, Reza Bayat, Daniel Zamanfar, Kioomars Golshekan, Adel Baghersalimi , Tabrizi Manijeh , Mohammad Hassan Mohammadi, Taher Cheraghi,
Volume 8, Issue 2 (5-2020)
Abstract
Introduction: Diabetes is the most common metabolic disease worldwide. Due to the arbitrary use of Urtica dioica among diabetics, this study aimed to investigate the effect of this herb on the control of diabetes.
Materials and Methods: This review study was performed using the Persian and English keywords, such as "type 1 diabetes and 2", "insulin", "herbal medicine", and "Urtica dioica" among valid databases, including PubMed, Elsevier, Wiley, Science Direct, and SID from 2000 to 2019. Subsequently, out of 127 articles, the results of 16 studies were examined in this review.
Results: The mechanisms investigated in these studies included DNA damage, increased numbers of beta-cells, increased expression of GLUT4 on the muscular cell surface, inhibition of atrophy of beta-cells, rearrangement of histology of islets of Langerhans, and stimulation of insulin secretion. Few positive results have been reported in the clinical models of diabetes on this extract.
Conclusion: According to the current study, Urtica dioica extract can control blood glucose levels through different mechanisms. Further studies with a wider number of samples to evaluate the exact mechanism of this extract on clinical specimens (in patients with type 1 and 2 diabetes) with and without insulin consumption and dosage are among the important issues in evaluating the effect of this extract.
