Introduction: The main responsible agents in coagulation cascade are proteins. Because of metabolism deficiency, this path could be disrupted in diabetes mellitus. Saliva is a great source of proteins, some of which have coagulation properties. In the current study, we aimed to compare blood coagulation time in the presence of whole saliva in diabetics and non-diabetics.

Materials and Methods: In this analytical, case-control study, 25 controlled diabetes patients with HbA₁c<7, who were referred to diabetes center for evaluating fasting blood sugar (FBS) and HbA_1c test were selected as the case group and 25 healthy individuals as the control group. At first, serum blood sugar of the patients was measured with glucometer. Afterwards, whole saliva that was gathered from the patients within 1 minute was poured on the second blood drop. Time of pouring saliva on blood to coagulation was recorded. For comparing the results of the two groups, t-test was used in SPSS 17.

Results: The results of this study did not show ant statistically significant correlation between blood coagulation time in the presence of saliva and vein or capillary FBS and HbA_1c (P>0.05).

Conclusions: Variation in proteins’ metabolism is a long-term process that needs sufficient time for significant effect. Since controlled diabetes patients were enrolled, the correlation of FBS and HbA_1c with coagulation time in the presence of whole saliva was not statistically significant.