Journal of
Diabetes Nursing
, abdalqani@gmail.com
Abstract: (22 Views)
Introduction: The past decade has witnessed a transformative era in insulin therapy, driven by advancements in the design of novel insulin analogues with superior pharmacokinetic profiles and the development of advanced delivery devices equipped with digital technology. These advances represent a significant departure from traditional blood glucose management paradigms. Objective: This systematic review examines the clinical evolution, evidence, and collective impact of insulin analogues and their delivery devices from 2014 to 2024. Our aim is to chart the progression from second-generation basal and ultra-rapid bolus analogues to the advent of automated insulin delivery systems and to analyze their impact on therapeutic outcomes and patient experience. Results: The development of ultra-long-acting basal analogues (glargine U300, degludec) and faster-acting prandial analogues has provided more physiologic insulin action, reducing hypoglycemia risk and improving glycemic variability. Concurrently, insulin delivery has evolved from simple mechanical injection to smart, connected systems. The introduction of connected pens, sensor-augmented pumps, and, most importantly, advanced hybrid closed-loop systems has leveraged continuous glucose monitoring data to automate real-time insulin titration. This synergy between tailored pharmacodynamics and responsive device algorithms has tangibly improved key metrics while alleviating the cognitive and psychological burden of daily diabetes management. Conclusion: The innovations of the past decade represent a paradigm shift from static insulin replacement towards dynamic, glucose-responsive physiologic mimicry. The co-evolution of analogues and devices has redefined standards of care, offering unprecedented control and quality of life. Future progress depends on improving accessibility, moving towards fully automated systems, and further personalizing therapy.
Type of Study: Research |
Subject:
Diabetic nursing teaching
Received: 2026/02/9 | Accepted: 2025/11/1
Received: 2026/02/9 | Accepted: 2025/11/1
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