Introduction: In the 21^st century, industrialization, globalization, increased life expectancy, and lifestyle changes are evident all over the world. One of the outcomes of these changes is alteration in disease pattern and enhanced prevalence of chronic diseases such as diabetes. Lifestyle and quality of life have a significant impact on exacerbation of diabetes symptoms, which in turn, will undermine the patient's psychological condition. We sought to predict depression based on lifestyle and quality of life in patients with type 2 diabetes.

Materials and Methods: The target population in this correlational study was all the type 2 diabetic patients visiting the Endocrinology and Metabolism Research Institute of Isfahan, Iran, during 2016. One hundred subjects were selected by using the purposive sampling method. All the participants completed a set of questionnaires including Health-Promoting Lifestyle Profile (Walker et al., 1987), Quality of Life (36-item short-form version; Ware and Sherbourne, 1992), and Beck Depression Inventory. To analyze the data, multivariate regression was performed in SPSS, version 20.

Results: The relationship of lifestyle with quality of life and depression was significant among the type 2 diabetic patients (P<0.001). Lifestyle and quality of life variables could predict depression in these patients

Conclusion: Psychological issues and quality of life of patients visiting healthcare centers should be considered to prevent aggravation of their symptoms.