Introduction: Diabetes is a serious chronic disease. Worries affect quality of life (QOL), treatment, and blood sugar management in diabetic patients. This study aims to determine the relationship of worry domains and QOL of patients with type II diabetes.

Materials and Methods: This descriptive-analytical study was conducted on 75 type II diabetes patients admitted to Amirolmomenin Hospital, Zabol, Iran. The study instruments were Worry domain and QOL questionnaires. Data were analyzed using SPSS version 22.

Results: The total mean score of worry domains was 61.36 out of 100. There was a significant, negative, linear relationship between all worry domains, except for the physical function domain, and QOL.

Conclusion: Given the high level of worry, especially due to financial and occupational issues, it is necessary to reduce patients' worries to ameliorate the direct side effects of worry, and in turn, improve QOL.