Introduction: Diabetes is a chronic and lifelong disease, which has many physical and psychological complications that may affect the quality of life. This study aimed to determine the effectiveness of mindfulness-based stress reduction on the quality of life in patients with type II diabetes.

Materials and Methods: This quasi-experimental study had a pretest-posttest design with a control group. The study population included 30 diabetic patients (%40 male), randomly divided into two groups of the experimental and control groups. This study benefited from Waren and Sherbourne quality of life questionnaire (SF-36). Eight sessions of Mindfulness-based stress reduction group training were conducted in eight weeks for the experimental group while the control group received no intervention. Both groups completed the SF-36 questionnaire before and after the intervention.

Results: Data analysis showed that some scales of quality of life in the experimental group significantly were improved in the posttest compared to the control group.

Conclusion: Based on the obtained results of this study, mindfulness-based stress reduction group training can be effective in improving the patients’ quality of life with type II diabetes mellitus.